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The design of an optimal framework for the prediction of cancer from high-dimensional and imbalanced microarray data is a challenging job in the fields of bioinformatics and machine learning. There are so many techniques for dimensionality reduction, but it is unclear which of these techniques performs best with different classifiers and datasets. This article focused on the independent component analysis (ICA) features (genes) extraction method for Naïve Bayes (N classification of microarray data, because ICA perfectly takes out an i