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y proposes the important IBS associated pathways and the network regulation mechanisms of the crucial ingredients. It reveals the multi-target synergistic effect of the crucial ingredient combinations for the novel therapy on IBS.Total dissolved gas (TDG) supersaturation caused by dam operations can cause fish gas bubble disease (GBD) and even fish kill. Few studies have examined the effects on pelagic species. Here, we examined the tolerance and avoidance characteristics of silver carp (Hypophthalmichthys molitrix), a pelagic fish widel