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However, after adjusting for the confounders (gender, gestational age, mode of delivery, type of feeding, parental education, and health status), significant association with the occurrence of 'demarcated opacities' (p 0.05) remained only for the children of trajectory V (heavier birth weights and rapid growth); no 'critical period' was found to be significantly associated with DDE. Infants with heavy birth weight and rapid growth during the first year of life were more vulnerable to the occurrence of DDE in terms of demarcated opacities in the