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The transcriptome of young Lox mutants showed alteration in dexamethasone (p = 9.83 × 10-3 and TGFβ-responsive genes (p = 7.42 × 10-29), and aortas from older C57Bl/6J Lox+/C285F mice showed both enhanced susceptibility to elastase (p 0.01 by ANOVA) and increased deposition of aggrecan (p 0.05). These findings suggest that the secreted Lox+/C285F mutants produce dysfunctional elastic fibers that show increased susceptibility to proteolytic damage. Over time, the progressive weakening of the connective tissue, modified by sex
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