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amyloid-positivity and cognitive impairment with odor identification suggests that low UPSIT performance may be a marker for AD pathophysiology in cognitive normal individuals, although impaired odor identification is associated with both AD and non-AD related neurodegeneration.NCT Registration Numbers NCT03373604; NCT02831283. Depression and Apolipoprotein E4 (APOE4) are associated with decreased cognitive function and differences in brain structure. This study investigated whether APOE4 status moderates the association between elevate