https://www.selleckchem.com/pr....oducts/salvianolic-a
Most of the approximately 60 genes that if mutated cause steroid-resistant nephrotic syndrome (SRNS) are highly expressed in the glomerular podocyte, rendering SRNS a "podocytopathy." We performed whole-exome sequencing (WES) in 1200 nephrotic syndrome (NS) patients. We discovered homozygous truncating and homozygous missense mutation in (synaptopodin-2) (p.Lys1124∗ and p.Ala1134Thr) in 2 patients with childhood-onset NS. We found SYNPO2 expression in both podocytes and mesangial cells; however, notably, immunofluorescence st
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