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(3) WUE was more sensitive to GPP, and variation in WUE was mainly contributed by GPP. Climate change and human activities tend to cause more variations in GPP rather than evapotranspiration (ET), but great differences exist for different regions and vegetation types. (4) There was a good consistency between the WUE variation calculated by the framework and the actual WUE variation (R2 = 0.95). Climate change dominated the increase of WUE in the TP with a contribution rate of 79.8%, while human activities tend to reduce WUE (-20.2%). Eco