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Lep activation induces the proliferation, encourages the intrusion and prevents the apoptosis of prostate cancer tumors cells through the ERK1/2 signaling pathway.Lep activation causes the expansion, encourages the invasion and inhibits the apoptosis of prostate cancer tumors cells through the ERK1/2 signaling pathway. Odds ratios (ORs) with matching 95% confidence intervals (95% CIs) had been assessed to assess the correlation between MTR D919G variant and PRAD risk. In inclusion,