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How Does ADHD Medication Work? Many people have found that ADHD medications help them focus, concentrate and manage their impulse-driven behavior. It can take some time to find the most effective drug and dosage for every individual. Certain medications can affect children's sleeping patterns. If they are sleeping better, this is a good indication that the medication is working. 1. Stimulants The most common prescription medication prescribed by healthcare professionals to treat ADHD