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The AUC of the NEOS score for 1-year poor functional status was 0.86 (95% CI 0.78-0.93, 0.001). The increased NEOS was associated with higher risk of 1-year poor functional status in patients with anti-NMDAR encephalitis. The NEOS score is considered a reliable predictor of the risk of 1-year poor functional status in Chinese patients with anti-NMDAR encephalitis. #link# This score could help to estimate the velocity of clinical improvement in advance. NCT02443350. This study provides Class III evidence that in patients with anti-NM