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Losartan therapy prevented every one of these changes and normalized the PGI2/TXA2 ratio in high-fat fed rats. We conclude that losartan may play advantageous activities on perivascular adipose muscle alterations and endothelial disorder through renovation of normal balance of vasoactive substances in this model.This study compared quantitative cartilage ultrasound metrics between people who have (n = 12) and without (letter = 12) arthroscopic cartilage harm after anterior cruciate ligamen