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In vitro researches from 3 set up Doc resistant CRPC (DocRPC) mobile outlines are in keeping with the medical findings showing DocRPC clients had diminished Enz-sensitivity as well as accelerated development of Enz-resistance via enhanced androgen receptor (AR) splicing variation 7 (ARv7) phrase. System dissection found that Doc treatment might boost the generation of ARv7 via modifying the MALAT1-SF2 RNA splicing complex. Preclinical researches utilizing in vivo mou