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Finally, it is important to recognize triggers to initiate a PC approach (important changes in disease trajectory, difficult or refractory symptoms, frequent defibrillator shocks or transplant/mechanical support prevision, functional capacity decline, severe comorbidities, communication needs also for advanced care planning).1Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome.Euthanasia and medical assistance in dying entail daunting ethical and moral challenges, in addition to a host o
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