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ADHD Treatment Medication Treatment for ADHD in adults typically involves psychosocial therapy and medication. The medications used to treat ADHD can include stimulants as well as nonstimulants. Stimulants like methylphenidate and Lisdexamfetamine work on chemical messengers within the brain to boost mood, concentration, and impulse control. Atomoxetine and guanfacine, both of both of which are non-stimulant ADHD drugs, are prescribed to teens, adults or children who are not respon