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This study determines the prevalence and particularities of headache and pain with neuropathic characteristics (NC) in a large French group of patients with pituitary adenoma (PA). Analysis of validated self-administered questionnaires, radiological characteristics and treatment strategies of PA was performed. Of the 221 sent questionnaires, 146 could be used for statistical analysis, 50% of which were completed by women. Among responders, 58.9% had pain 30.1% migraine, 15.7% pain with NC and 13.1% other types of pain. Migraine was more