https://www.selleckchem.com/pr....oducts/sodium-2-1h-i
REC-2282is a novelhistone deacetylase inhibitorthat has shown antitumoractivity in in vitro and in vivo models of malignancy. The aims of this study were to characterize the population pharmacokinetics of REC-2282 (AR-42) from the first-in-human (NCT01129193) and phase I acute myeloid leukemia trials (NCT01798901) and to evaluate potential sources of variability. Additionally, we sought to understand alternate body size descriptors as sources of inter-individual variability (IIV), which was significant for dose-nor
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