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Ambient nitrogen dioxide (NO ) is a common air pollutant in developing countries and causes skin conditions, but its effect on eczema in subtropical areas is not clear in China. To measure the effect of short-term exposure of NO on the incidence of eczema and the change of outpatient visits. Data of daily temperature, air pollutants, and outpatient visits from 2013 to 2018 were collected in a row. The generalized additive model (GAM) and Poisson distribution were used to assess the association between short-term exposure of NO and the ou