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Best Medication For ADHD The majority of ADHD treatment plans include medications. But finding the best dosage and medication can take time. Be patient and open with your doctor or specialist. Stimulants boost the levels of chemicals that regulate behavior in the brain. They are available in short-acting and long-acting formulations. Short-acting drugs peak within a few hours and must be taken 3 times a day. Long-acting medications last 8-12 hours and are usually taken every day. Stimulants Adults may not benefit from stimu