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While IM-MS is an ever more effective analytical method, considerable bottlenecks pertaining to the resolution of dimensions have actually kept it from becoming broadly requested biological analyses. Presently, IM-MS-based measurements also remain limited in terms of their sensitiveness when compared with state of the art MS-based methods alone. Frameworks for Lossless Ion Manipulations (SLIM)-based IM separations supply a basis for beating these bottlenecks, handling dilemmas