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87, p 0.001; men, HR = 0.83, p 0.001; women, HR = 0.76, p 0.001). The included studies were homogeneous (all, p = 0.43; men, p = 0.9; women, p = 0.49). Sensitivity analysis confirmed the robustness of these summary effects. Publication bias was detected, which was adjusted for by a trim-and-fill method. The adjusted results showed significant summary effects (all, HR = 0.88, p = 0.002; men, HR = 0.83, p 0.001; women, HR = 0.77, p 0.001). The present meta-analysis suggests that the serum UA level could be a pr