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7% vs. 22.1% (p 0.001). Multivariable analysis showed that PORT was an independent prognostic factor for OS (HR=0.59, 95% CI 0.43-0.82, p= 0.001) and CSS (HR=0.56, 95% CI 0.41-0.78, p= 0.001). Subgroup analysis showed that patients in the following subgroups could benefit from PORT age ≤ 70, diagnosed in the later period (2010-2015), white race, squamous cell carcinoma, grade III-IV, lobectomy, stage T3-4, or with positive regional nodes ≤3 or 3. For patients with ypN2 NSCLC after NCS, PORT significantly improves OS and CSS. The
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