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Muscle interstitial concentrations derived from our study may also be weighed against previously reported values calculated using microdialysis or centrifugation strategy. Finally, the new pair of biodistribution information created using ELISA are widely used to improve the PBPK model for mAbs.Alkaptonuria (AKU) is a rare metabolic disease correlated with the scarcity of homogentisate 1,2-dioxygenase and leading to a build up of the metabolite homogentisic acid (HGA) and that can be af