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28; 95% CI 2.32-4.62) and low leukocyte counts in the CSF (OR 2.86; 95% CI 1.47-5.57). Compared with enterovirus, bacterial etiology (OR 7.50; 95% CI 1.0-56.72), herpes simplex encephalitis (OR 11.81; 95% CI 1.44-96.64), autoimmune encephalitis (OR 22.55; 95% CI 3.68-138.16) and other viral infections (OR 5.83; 95% CI 1.09-31.2 increased the risk of PICU admission. Data from this national collaborative network of pediatric patients with encephalitis allow early identification of children at risk of needing advanced care and can guide t