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Heterocycles constitute the largest and most diverse family of organic compounds that have received extensive interest owing to their popularity in many natural products, pharmaceuticals, and materials [...].Vaccination is one of the most successful strategies to prevent human infectious diseases. Combinatorial adjuvants have gained increasing interest as they can stimulate multiple immune pathways and enhance the vaccine efficacy of subunit vaccines. We investigated the adjuvanticity of Aluminum (alum) in combination with rASP-1, a protei