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ADHD Stimulant Medication Stimulants can help 70 percent to 80% of children and adults suffering from ADHD. They reduce symptoms by increasing levels of dopamine and norepinephrine. The medicines begin to work in about 30 to 45 minutes, and last 3 to 6 hours. These medicines are available in liquid or chewable tablet form. Nonstimulant medicines could be prescribed by your doctor to supplement stimulants. They include atomoxetine and Guanfacine. Short-acting Stim