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Median interval from the first PJI to the npPJI was 26 months. New-pathogen prosthetic joint infections (npPJIs) s more frequently spread hematogenously (60% vs 33%) and were predominantly caused by Staphylococcus (36%) or Streptococcus (33%) species. Multivariate analysis identified two risk factors chronic dermatitis (odds ratio 6.23; P0.05) and cardiovascular diseases (odds ratio 2.71; P0.01). A curative strategy was applied to 70% DAIR (29%), one-stage (28%), two-stage exchange arthroplasty (7%) or other strategies (7%). The others