Causes of Truck Crash Accidents When a truck accident occurs the driver could be the cause, but there are many other factors that could contribute to an accident. Some of the most common causes are fatigue of the driver or impaired driving, as well as trucks loaded with hazardous cargo. The makers of these products could also be held responsible for any damages. In must be sought as soon as is possible, and you should see your primary doctor if you suffer injuries. Document evidence of the crash and exchange information with the other party.