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RCN1 expression in NPC areas and cells had been determined. The biological purpose of RCN1 on NPC cellular apoptosis had been evaluated via gain- and loss-of-function experiments in 5-8 F/ADM and 5-8 F cells by delivering si-RCN1 and RCN1-vector. The event of endoplasmic reticulum (ER) stress on mobile apoptosis was calculated with the involvement for the PERK-CHOP signaling path. Moreover, tumefaction development in nude mice was carried out to evaluate the success condition and RCN1 effects in vivo. RCN1 en