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8 mmHg) (P = 0.001, for all comparisons). No differences in PvCO2 were identified in horses living between 1000 and 3000 masl. This study showed that the Htc, Hb, and PvCO2 of horses living at sea level were different compared to those in healthy horses living at altitudes ≥ 1000 masl. However, differences in TPP and electrolyte concentrations were not identified.Proteins approximately behave as molecular clocks, accumulating amino acid replacements at a more or less constant rate. Nonetheless, each protein displays a characteristic rate of evolutio