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This study is the first comprehensive analysis of symmetric arginine dimethylation using clinical samples and extends the number of known in vivo SDMA sites. The data obtained are available via ProteomeXchange with the identifier PXD015653. This article is protected by copyright. All rights reserved.With the advent of layered two-dimensional crystals, surface dangling bonds-free planar sheets provide one emergent type of growth substrates to explore the new possibilities of crystal synthesis. While graphene has been widely exploited as t