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Glioblastomas with methylation of the promoter region of the O(6)-methylguanine-DNA methyltransferase ( ) gene exhibit increased sensitivity to alkylating chemotherapy. Quantitative assessment of the promoter methylation status might provide additional prognostic information. The aim of our study was to determine a quantitative methylation threshold for better survival among patients with glioblastomas. We included consecutive patients ≥18 years treated at our department between 11/2010 and 08/2018 for a glioblastoma, wildtype, undergoing