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nalysis showed a return to the initial phenotype after 24 hours for cultures grown in light/dark (12 h/12 h) cycles; this did not occur for cultures grown in the dark. Finally, correlation coefficients (R 0.7) were found for glycogen, all amino acids, and chlorophyll a when comparing specific Raman bands to other experimental results. ©2020 Tanniche et al.Background During their long evolution, Synechocystis sp. PCC6803 developed a remarkable capacity to acclimate to diverse environmental conditions. In this study, Raman