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Ultimately, we utilized small interfering RNA (siRNA) to knockdown Mof in α-TC1-6 and unravel the process controlling α-cell mass and glucagon secretion. Outcomes Mof was mainly expressed in α-cells. Global Mof deficiency led to reduced sugar levels, attributed by reduced α/β-cell ratio and glucagon release. α-cell-specific Mof-deficient mice exhibited similar modifications, with additional reduced prohormone convertase 2 (PC2)-positive α-cell mass, in charge of less glucagon, and improve
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