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Here, we investigated whether a pharmacological strategy focusing on different aspects of the reabsorption system could possibly be used to reduce the uptake of [99mTc]Tc-ZHER2395 affibody molecule in kidneys. Pre-injection of probenecid, furosemide, mannitol or colchicine had no impact on activity uptake in kidneys set alongside the control group. Mice pre-injected with maleate and fructose had 33% and 51% decrease in the kidney-associated activity, correspondingly, compared to the con