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Survival analysis showed a significant difference between the reclassified T2 and T3 stages (P0.001). The results were replicated in the validation samples. The proposed staging system for defining T2 and T3 stage NPC appears to be superior to the AJCC 8th edition. It could improve prognosis and optimize the treatment selection. The proposed staging system for defining T2 and T3 stage NPC appears to be superior to the AJCC 8th edition. It could improve prognosis and optimize the treatment selection.Covalent organic frameworks (COFs