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of the rivers. Thus, the study highlighted that the urban settlements and agricultural lands have a considerable influence on river quality thereby triggering the increase in trace element concentrations. Therefore, the study necessitates on the continuous monitoring of river along with adoption of stringent discharge protocols. Folate may be involved in the detoxification of heavy metals. This has been demonstrated in animal studies, in in vivo and in vitro studies, and clinical evaluations. However, knowledge regarding the association