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Amazingly, brief side-chain supplement D analogs were discovered to be biologically active substances. Therefore, right here we tested unique derivatives of pregnacalciferol with an extra hydroxyl at the conclusion of the truncated side chain, PRI-1203 and PRI-1204, as to their potency against peoples melanoma A375 and RPMI7951 cell outlines. Tested compounds are geometric isomers, with 19-methylene situated in PRI-1203 like in a calcitriol molecule, but reversed into the PRI-1
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