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(volume, thickness). An improvement in color was observed at week 4 in the timolol group, and timolol was well tolerated with no systemic adverse effects. In this randomized clinical trial, results demonstrated that topical timolol is well tolerated for the treatment of early proliferative IH but provides limited benefit in lesion resolution when given during the early proliferative stage. EudraCT Identifier 2013-005199-17. EudraCT Identifier 2013-005199-17. Persistent paranoia is common among patients with psychosis. Cognitive-behavi