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Docking results revealed that 3b, elicited binding affinities to ARO comparable to those of letrozole. The obtained results support the therapeutic importance of some of these compounds as anti-BC agents in light of the simple methodology used for their synthesis. Their design offered a way for the optimization and development of apoptotic quinazolinone-based ARO and EGFR inhibitors. The obtained results support the therapeutic importance of some of these compounds as anti-BC agents in light of the simple methodology used for their synt