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Self-care practices in diabetes patients are crucial to keep the illness under managed and prevent complications. Despite this, relatively little information is available regarding the level of self-care practice and associated factors among individuals with diabetes mellitus in the study area. Therefore, this study aimed to assess self-care practice and its associated factors among individuals with diabetes mellitus in Deber Berhan referral hospital, Northeast Ethiopia. A hospital-based cross-sectional study was conducted among 405 di