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Our outcomes revealed a critical contribution regarding the inositol-requiring enzyme-1 (IRE1) supply associated with the unfolded protein response to ZIKV-induced neurological and testicular complications. Notably, inhibiting IRE1 signaling pathway activation with KIRA6 (Kinase-Inhibiting RNAse Attenuator 6), a selective little molecule IRE1 inhibitor that promotes cellular success, potently reverted the ZIKV-induced perturbations of the key gene expressions related to neurogenesis and spermat