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In particular, REHHO was able to achieve superior performances against HHO in all conducted benchmark problems. Besides that, results showed that faster convergence was obtained from the embedded rules. Furthermore, REHHO was able to outperform several recent and state-of-the-art optimization algorithms. Ferritin is a protein that plays an important role in iron metabolism, it consists of two subunits heavy chain (FTH) and light chain (FTL). Elevated expression of FTL is observed in multiple malignancies. Recent studies have found that th