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Non Stimulant ADHD Medication Stimulants boost dopamine and neurotransmitters norepinephrine and norepine that aid in motivation and alertness, concentration and effort. They also aid in focus and concentration. Non-stimulant ADHD medication is usually prescribed when stimulants aren't working, cause intolerable side effects or a person is unable to take them due to medical reasons. Clonidine (Kapvay), and guanfacin