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Stimulants Are the Most Effective ADHD Medication For Adults The most common prescription medication used by health professionals to treat ADHD among adults is stimulants. They are used to increase the levels of certain neurotransmitters (chemicals) in your brain. This improves attention and decreases the risk of impulsivity. Antidepressants such as Strattera (atomoxetine) and Wellbutrin/Zyban, as well as Bupropion (bupropion), also help control ADHD. boost the levels of norepinephrine in the brain. St