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left hippocampus. Quantitative single-voxel and multi-voxel H-magnetic resonance spectroscopy can provide valuable information to detect alterative brain neurometabolites characteristics in patients with subjective cognitive decline plus. N-acetylaspartate concentrations may be used as one of the earliest neuroimaging markers at this stage, while N-acetylaspartate/myoinositol ratio could be more suitable for monitoring Alzheimer's disease progression. Quantitative single-voxel and multi-voxel 1H-magnetic resonance spectroscopy can provid