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Furthermore, Exos reached the substantia nigra through the blood-brain barrier (BB in vivo, relieved apomorphine-induced asymmetric rotation, reduced substantia nigra dopaminergic neuron loss and apoptosis, and upregulated the level of dopamine in the striatum. These results demonstrate that hucMSCs-Exos have a treatment capability for PD and can traverse the BBB, indicating their potential for the effective treatment of PD.Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here,