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Male ob/ob mice exhibited LVH, cardiac inflammation, and oxidative anxiety. Using RNA-seq evaluation, we identified that an iron uptake-associated gene, transferrin receptor, ended up being upregulated in obese ob/ob mice with LVH. Caloric limitation attenuated myocyte hypertrophy, cardiac infection, fibrosis, and oxidative stress in ob/ob and db/db mice. Furthermore, we discovered that caloric constraint corrected iron homeostasis-related lipocalin 2, divalent steel transporter 1, transfe