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ADHD in Adults Undiagnosed Being a person with a diagnosis of undiagnosed ADHD can be extremely challenging, resulting in years of guilt and low self-esteem. This can lead depression as well as mental health issues and even substance abuse. As with children being diagnosed with ADHD in adults requires a thorough medical history that may include a psychological exam and a discussion with the person's close family members for perspective on childhood behavior. 1. Problems in Focusing Peopl