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Inadequate HD badly affects quality of life and improving adequacy refines many components of quality of life. Inadequate HD badly affects quality of life and improving adequacy refines many components of quality of life. Migraine is a common neurological disease with extremely debilitating, but fully reversible symptoms. Women suffer from migraine more often than men. It was assumed that fluctuation of oestrogen level during menstrual cycle is one of many factors responsible for more frequent migraine attacks. The second-to-fourth dig