https://www.selleckchem.com/pr....oducts/shp099-dihydr
Trepanation performed systematically in Greece since the Bronze Age (ca. 2,000 BC). Hippocrates who rationally conceived medicine, codified the pre-existing empirical knowledge. The trepanations from Akanthos show technical similarities but also discrepancies from the Hippocratic recommendations, confirming the mental and technical readiness of the ancient surgeon. The synchronous to Hippocrates trepanations from Akanthos, provide the opportunity to compare physical evidence with the written sources. The frequency of trep